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Science 8 July 1977:
Vol. 197. no. 4299, pp. 183 - 186
DOI: 10.1126/science.301658
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Articles

Science, Vol 197, Issue 4299, 183-186
Copyright © 1977 by American Association for the Advancement of Science

articles

Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone

Y Hosobuchi, JE Adams, and R Linchitz

Relief of intractable pain was produced in six human patients by stimulation of electrodes permanently implanted in the periventricular and periaqueductal gray matter. The level of stimulation sufficient to induce pain relief seems not to alter the acute pain threshold. Indiscriminate repetitive stimulation produced tolerance to both stimulation-produced pain relief and the analgesic action of narcotic medication; this process could be reversed by abstinence from stimulation. Stimulation-produced relief of pain was reversed by naloxone in five out of six patients. These results suggest that satisfactory alleviation of persistent pain in humans may be obtained by electronic stimulation.


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