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Science 8 July 1977:
Vol. 197. no. 4299, pp. 177 - 179
DOI: 10.1126/science.301657
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Articles

Science, Vol 197, Issue 4299, 177-179
Copyright © 1977 by American Association for the Advancement of Science

articles

Nude mouse: a new experimental model for Pneumocystis carinii infection

PD Walzer, V Schnelle, D Armstrong, and PP Rosen

Experimental infection with both human- and rat-derived Pneumocystis carinii has been produced in nude mice by intrapulmonary injection of lung homogenates that contained P. carinii and by environmental transmission. Most infected mice did not appear ill, and their lungs exhibited a mild and nonspecific inflammatory response. Thus, P. carinii can be transmitted from one animal species to another, and this result suggests that a defect in thymic-dependent lymphocytes is important in the development of the infection. Experimental work with P. carinii in the nude mouse should be performed in isolators because of the communicability of the organism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Suppression of Alveolar Macrophage Apoptosis Prolongs Survival of Rats and Mice with Pneumocystis Pneumonia..
M. E. Lasbury, P. J. Durant, C. A. Ray, D. Tschang, R. Schwendener, and C.-H. Lee (2006)
J. Immunol. 176, 6443-6453
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T Cell Costimulatory Molecule Function Determines Susceptibility to Infection with Pneumocystis carinii in Mice.
J. M. Beck, M. B. Blackmon, C. M. Rose, S. L. Kimzey, A. M. Preston, and J. M. Green (2003)
J. Immunol. 171, 1969-1977
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Early Acquisition of Pneumocystis carinii in Neonatal Rats as Evidenced by PCR and Oral Swabs.
C. R. Icenhour, S. L. Rebholz, M. S. Collins, and M. T. Cushion (2002)
Eukaryot. Cell 1, 414-419
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Pneumocystis carinii f. sp. hominis Is Not Infectious for SCID mice.
I. Durand-Joly, E. M. Aliouat, C. Recourt, K. Guyot, N. Francois, M. Wauquier, D. Camus, and E. Dei-Cas (2002)
J. Clin. Microbiol. 40, 1862-1865
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Widespread Occurrence of Pneumocystis carinii in Commercial Rat Colonies Detected Using Targeted PCR and Oral Swabs.
C. R. Icenhour, S. L. Rebholz, M. S. Collins, and M. T. Cushion (2001)
J. Clin. Microbiol. 39, 3437-3441
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Genetics of Surface Antigen Expression in Pneumocystis carinii.
J. R. Stringer and S. P. Keely (2001)
Infect. Immun. 69, 627-639
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Pneumocystis carinii and Geographic Clustering . Evidence for Transmission of Infection.
J. M. Beck (2000)
Am. J. Respir. Crit. Care Med. 162, 1605-1606
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Geographic Clustering of Pneumocystis carinii Pneumonia in Patients with HIV Infection.
M. N. DOHN, M. L. WHITE, E. M. VIGDORTH, C. RALPH BUNCHER, V. S. HERTZBERG, R. P. BAUGHMAN, A. GEORGE SMULIAN, and P. D. WALZER (2000)
Am. J. Respir. Crit. Care Med. 162, 1617-1621
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Pneumocystis carinii Pneumonia Among Patients Without AIDS at a Cancer Hospital.
K. A. Sepkowitz, A. E. Brown, E. E. Telzak, S. Gottlieb, and D. Armstrong (1992)
JAMA 267, 832-837
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Pneumocystis Pneumonia: From Bench to Clinic.
H. Masur, H. C. Lane, J. A. Kovacs, C. J. Allegra, and J. C. Edman (1989)
Ann Intern Med 111, 813-826
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Delayed Development of Pneumocystis Pneumonia Following Administration of Short-Term High-Dose Trimethoprim-Sulfamethoxazole.
L. J. WOLFF and R. L. BAEHNER (1978)
Arch Pediatr Adolesc Med 132, 525-526
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