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Science 1 July 1977:
Vol. 197. no. 4298, pp. 89 - 91
DOI: 10.1126/science.194312
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Articles

Science, Vol 197, Issue 4298, 89-91
Copyright © 1977 by American Association for the Advancement of Science

articles

Physiological evidence for habenula as major link between forebrain and midbrain raphe

RY Wang and GK Aghajanian

The lateral habenula is one of the few forebrain areas that project to the midbrain raphe nuclei. Electrical stimulation of the habenula markedly suppressed serotonergic neurons in the midbrain raphe. The suppression was blocked by systemic or microiontophoretic administration of picrotoxin, which suggests that gamma-aminobutyric acid is the inhibitory transmitter in the habenula-raphe pathway. These results support the concept that the habenula may serve a pivotal role in funneling information from the forebrain to the midbrain raphe.


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