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Science 24 June 1977:
Vol. 196. no. 4297, pp. 1467 - 1469
DOI: 10.1126/science.867045
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Articles

Science, Vol 196, Issue 4297, 1467-1469
Copyright © 1977 by American Association for the Advancement of Science

articles

Somatostatin: analogs with selected biological activities

M Brown, J Rivier, and W Vale

[D-Cys14]-Somatostatin is the first analog of somatostatin found to be more potent in inhibiting glucagon and growth hormone secretion that it is in inhibiting insulin secretion. [D-Trp8]-Somatostatin is eight to ten times more potent than somatostatin in inhibiting insulin, glucagon, and growth hormone secretion. [D-Trp8, D-Cys14]-Somatostatin is more potent than [D-Cys14]-Somatostatin, but retains its relative selectivity in being a more potent inhibitor of the secretion of glucagon and growth hormone than of insulin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry.
S. P. Rohrer, E. T. Birzin, R. T. Mosley, S. C. Berk, S. M. Hutchins, D. Shen, Y. Xiong, E. C. Hayes, R. M. Parmar, F. Foor, et al. (1998)
Science 282, 737-740
   Abstract »    Full Text »
Identification of Ligand Binding Determinants in the Somatostatin Receptor Subtypes 1and 2.
G. Liapakis, D. Fitzpatrick, C. Hoeger, J. Rivier, R. Vandlen, and T. Reisine (1996)
J. Biol. Chem. 271, 20331-20339
   Abstract »    Full Text »    PDF »
Aspects of hypothalamic regulation of the pituitary gland.
A. Schally (1978)
Science 202, 18-28
   PDF »


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