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Science 17 June 1977:
Vol. 196. no. 4296, pp. 1343 - 1345
DOI: 10.1126/science.17159
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Articles

Science, Vol 196, Issue 4296, 1343-1345
Copyright © 1977 by American Association for the Advancement of Science

articles

Localization of nigral dopamine-sensitive adenylate cyclase on neurons originating from the corpus striatum

PF Spano, M Trabucchi, and G Di Chiara

Nigral basal adenylate cyclase and dopamine-sensitive adenylate cyclase, glutamate decarboxylase, choline acetyltransferase, and tyrosine hydroxylase activities were measured in rats with hemitransections at various levels or with electrolytic lesions of the medial forebrain bundle or the crus cerebri. The loss of nigral dopamine-sensitive adenylate cyclase activity after the various brain lesions was correlated with loss of nigral glutamic acid decarboxylase but not that of tyrosine hydroxylase; nigral choline acetyltransferase was unaffected in all cases. The data indicate that the nigral dopamine-sensitive adenylate cylase activity may be localized on neurons afferent to the nigra, probably originating from the globus pallidus and possibly from the tail of the caudate. The results suggest that dopamine, released from nigral dendrites, may influence dopaminergic activity indirectly by modulating impulses transmitted to the nigrostriatal neurons through the crus cerebri.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Kainic acid lesions of the striatum dissociate amphetamine and apomorphine stereotypy: similarities to Huntingdon's chorea.
S. Mason, P. Sanberg, and H. Fibiger (1978)
Science 201, 352-355
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