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Science 10 June 1977:
Vol. 196. no. 4295, pp. 1216 - 1219
DOI: 10.1126/science.870976
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Articles

Science, Vol 196, Issue 4295, 1216-1219
Copyright © 1977 by American Association for the Advancement of Science

articles

Sickle hemoglobin aggregation: a new class of inhibitors

Votano JR, M Gorecki, and A Rich

A number of tri- and tetrapeptides have been found to inhibit aggregation and gelation of deoxygenated sickle cell hemoglobin. These inhibitors have hydrophobic phenylalanine residues at one end and hydrogen bonding lysine or arginine side chains at the other end. The backbone is not very specific. The inhibitors do not modify the oxygen carrying properties of hemoglobin. When the inhibitor and sickle hemoglobin are put inside reconstituted cells, the erythrocytes do not sickle upon deoxygenation. Compounds of this type may develop useful agents in the therapy of sickle cell anemia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rational approaches to chemotherapy: antisickling agents.
I. Klotz, D. Haney, and L. King (1981)
Science 213, 724-731
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