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Science 6 May 1977:
Vol. 196. no. 4290, pp. 663 - 664
DOI: 10.1126/science.193182
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Articles

Science, Vol 196, Issue 4290, 663-664
Copyright © 1977 by American Association for the Advancement of Science

articles

Human breast cancer: biologically active estrogen receptor in the absence of estrogen?

DT Zava, GC Chamness, KB Horwitz, and WL McGuire

The human breast cancer cell line MCF-7 does not require estrogen for growth, but paradoxically its growth is inhibited by antiestrogens. Our results show that, unlike normal target cells, MCF-7 cells carry most of their estrogen receptors in their nuclei even when these receptors are not charged with estrogens. The receptors for androgen and for progesterone, on the other hand, are localized in the cytoplasm as usual. Therefore, it is possible that the growth of these abnormal cells is stimulated by estrogen receptor in spite of the absence of the hormone and that the binding of antiestrogen molecules antagonize this stimulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structure, Synthesis, and Molecular Cloning of Dermaseptins B, a Family of Skin Peptide Antibiotics.
S. Charpentier, M. Amiche, J. Mester, V. Vouille, J.-P. Le Caer, P. Nicolas, and A. Delfour (1998)
J. Biol. Chem. 273, 14690-14697
   Abstract »    Full Text »    PDF »
Progesterone regulation of the occupied form of nuclear estrogen receptor.
W. Okulicz, R. Evans, and W. Leavitt (1981)
Science 213, 1503-1505
   Abstract »    PDF »
Estrogen and the growth of breast cancer: new evidence suggests indirect action.
S. Shafie (1980)
Science 209, 701-702
   Abstract »    PDF »
Human breast cancer: androgen action mediated by estrogen receptor.
D. Zava and W. McGuire (1978)
Science 199, 787-788
   Abstract »    PDF »
Steroid Receptors.
J. A. Holt, T. A. Caputo, and K. M. Kelly (1977)
JAMA 238, 2263-2264
   Abstract »    PDF »


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