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Science 6 May 1977:
Vol. 196. no. 4290, pp. 653 - 654
DOI: 10.1126/science.193181
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Articles

Science, Vol 196, Issue 4290, 653-654
Copyright © 1977 by American Association for the Advancement of Science

articles

Tumor cell collagenase and its inhibition by a cartilage-derived protease inhibitor

KE Kuettner, L Soble, RL Croxen, B Marczynska, J Hiti, and E Harper

Human osteosarcoma and mammary carcinoma cells were cultured separately in a medium supplemented with fetal calf serum, until they were confluent. The medium was then replaced by serum-free medium supplemented with heparin. Both cell cultures secreted collagenase, and this activity was inhibited by a cartilage-derived protein of low molecular weight. Since cartilage is rarely invaded by neoplasms, the presence of this inhibitor may play an important role in the regulation of tumor invasion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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W. A. Weiger, M. Smith, H. Boon, M. A. Richardson, T. J. Kaptchuk, and D. M. Eisenberg (2002)
Ann Intern Med 137, 889-903
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Inhibition of bone resorption in vitro by a cartilage-derived anticollagenase factor.
J. Horton, F. Wezeman, and K. Kuettner (1978)
Science 199, 1342-1345
   Abstract »    PDF »
Platelet factor 4: an inhibitor of collagenase.
J Hiti-Harper, H Wohl, and E Harper (1978)
Science 199, 991-992
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Science. ISSN 0036-8075 (print), 1095-9203 (online)