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Science 29 April 1977:
Vol. 196. no. 4289, pp. 538 - 540
DOI: 10.1126/science.403608
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Articles

Science, Vol 196, Issue 4289, 538-540
Copyright © 1977 by American Association for the Advancement of Science

articles

Antileukemia activity in the Osillatoriaceae: isolation of Debromoaplysiatoxin from Lyngbya

JS Mynderse, RE Moore, M Kashiwagi, and TR Norton

Chloroform extracts of several seaweeds, of the family Oscillatoriaceae, from Enewetak Atoll, Marshall Islands, display activity against P-388 lymphocytic mouse leukemia. A P-388 active compound, debromoaplysiatoxin, has been isolated from Lyngbya gracilis and characterized. This compound also has dermonecrotic activity and may be the dermatitis-producing substance in L. majuscula, the causative agent of "swimmers' itch" outbreaks in Hawaiian waters.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Seaweed dermatitis: structure of lyngbyatoxin A.
J. Cardellina 2nd, F. Marner, and R. Moore (1979)
Science 204, 193-195
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