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Science 22 April 1977:
Vol. 196. no. 4288, pp. 440 - 441
DOI: 10.1126/science.15317
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Articles

Science, Vol 196, Issue 4288, 440-441
Copyright © 1977 by American Association for the Advancement of Science

articles

Tris buffer attenuates acetylcholine responses in Aplysia neurons

WA Wilson, MT Clark, and TC Pellmar

The commonly used buffering agent tris(hydroxymethyl)methylamine (tris) antagonizes the action of iontophoretically applied acetylcholine on neurons of Aplysia californica. Concentrations of 5 to 10 millimolar tris markedly reduced both excitatory and inhibitory responses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The structure of crystalline tris: a plastic crystal precursor, buffer, and acetylcholine attenuator.
R Rudman, D Eilerman, and S. La Placa (1978)
Science 200, 531-533
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