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Science 15 April 1977:
Vol. 196. no. 4287, pp. 331 - 333
DOI: 10.1126/science.557842
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Articles

Science, Vol 196, Issue 4287, 331-333
Copyright © 1977 by American Association for the Advancement of Science

articles

Membrane currents examined under voltage clamp in cultured neuroblastoma cells

WH Moolenaar and I Spector

Examination of ionic membrane currents in a voltage-clamped neuronal cell line derived from the mouse C1300 neuroblastoma disclosed four kinetically different components: sodium, potassium, calcium, and leakage current. The kinetics, voltage dependence, and pharmacological properties of the sodium and potassium currents qualitatively resemble those of the corresponding currents in squid giant axon and frog myelinated nerve fiber, suggesting that the molecular structures of the sodium and potassium channels in neuroblastoma are similar to those of the non-mammalian preparations.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)