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Science 15 April 1977:
Vol. 196. no. 4287, pp. 328 - 330
DOI: 10.1126/science.191911
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Articles

Science, Vol 196, Issue 4287, 328-330
Copyright © 1977 by American Association for the Advancement of Science

articles

Antigen-antibody reactions in rat brain sites induce transient changes in drinking behavior

CA Williams Jr and N Schupf

The septum or hypothalamus of rat brain was injected through implanted cannulas with antibody against membrane antigens in the rat brain or with antibody against exogenous soluble antigens (such as ovalbumin) followed by the specific antigen. Both immunological systems produced a moderate but highly significant decrease in drinking by thirsty rats. This phenomenon is suggested as an experimental model for behavioral disorders resulting from nondegenerative, immunological processes in the brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Food and Chemical Sensitivity: Clinical and Immunologic Correlates.
J. J. McGovern Jr, J. A. Lazaroni, M. F. Hicks, J. C. Adler, and P. Cleary (1983)
Arch Otolaryngol Head Neck Surg 109, 292-297
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