Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 April 1977:
Vol. 196. no. 4287, pp. 303 - 305
DOI: 10.1126/science.191910
Prev | Table of Contents | Next

Articles

Science, Vol 196, Issue 4287, 303-305
Copyright © 1977 by American Association for the Advancement of Science

articles

A phospholipid derivative of cytosine arabinoside and its conversion to phosphatidylinositol by animal tissue

CR Raetz, MY Chu, S Srivastava, and JG Turcotte

We have synthesized an analog (ara-CDP-DL-dipalmitin) of cytidine diphosphate diglyceride (CDP-diglyceride) in which the antitumor drug, cytosine arabinoside, is substituted for the cytidine moiety. Enzymes in rat and human liver convert this analog to phosphatidylinositol, thereby releasing cytosine arabinoside-5'-monophosphate, an obligatory intermediate in the activation of cytosine arabinoside. Unlike cytidine diphosphate diglyceride, however, ara-CDP-DL-diapalmitin is not an efficient substrate for phosphatidylglycerophosphate synthesis in liver or phosphatidylserine in Escherichia coli. The antitumor activity of ara-CDP-DL-dipalmitin in mice bearing L5178Y leukemia is described.




To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)