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Science 1 April 1977:
Vol. 196. no. 4285, pp. 79 - 81
DOI: 10.1126/science.841345
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Articles

Science, Vol 196, Issue 4285, 79-81
Copyright © 1977 by American Association for the Advancement of Science

articles

Homeostasis during hypoglycemia: central control of adrenal secretion and peripheral control of feeding

EM Stricker, N Rowland, CF Saller, and MI Friedman

Intravenous infusions of manose or B-hydroxybutyrate, metabolic fuels which can be oxidized by brain, abolished adrenal discharge of epinephrine in rats during insulin-induced hypoglycemia, whereas infusion of fructose, a sugar which does not cross the blood-brain barrier, did not. In contrast, increased feeding behavior during hypoglycemia was prevented both by the sugars and by B-hydroxybutyrate. Thus, while the sympathetic response during marked hypoglycemia may have been initiated by alterations in cerebal metabolism, the feeding response evidently was not, and a decrease in the utilization of glucose per se does not appear to be the critical stimulus in either case.


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