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Science 25 March 1977:
Vol. 195. no. 4284, pp. 1354 - 1356
DOI: 10.1126/science.65791
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Articles

Science, Vol 195, Issue 4284, 1354-1356
Copyright © 1977 by American Association for the Advancement of Science

articles

Neurophysin biosynthesis: conversion of a putative precursor during axonal transport

H Gainer, Y Sarne, and MJ Brownstein

[35S]Cysteine injected adjacent to the supraoptic nucleus of the rat is rapidly incorporated into a 20,000-dalton protein that, in time, is converted to a 12,000-dalton labeled protein, neurophysin. This putative precursor of neurophysin appears to be synthesized in the supraoptic nucleus and transformed to neurophysin and related peptides during axonal transport to the neurohypophysis.


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