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Science 11 March 1977:
Vol. 195. no. 4282, pp. 994 - 996
DOI: 10.1126/science.841324
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Articles

Science, Vol 195, Issue 4282, 994-996
Copyright © 1977 by American Association for the Advancement of Science

articles

25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol: conversion impaired by systemic metabolic acidosis

SW Lee, J Russell, and LV Avioli

An acute systemic acidosis in vitamin D depleted rats that was induced by ammonium chlroide feeding resulted in defective biological hydroxylation of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. Impaired enzymatic hydroxylation occurred despite the presence of either hypophosphatemia or hypocalcemia. The data suggest that acidosis interfers with the adaptive enzymatic control of 25-hydroxycholecalciferol metabolism in the vitamin D depleted state.


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