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Science 11 March 1977:
Vol. 195. no. 4282, pp. 991 - 994
DOI: 10.1126/science.841323
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Articles

Science, Vol 195, Issue 4282, 991-994
Copyright © 1977 by American Association for the Advancement of Science

articles

Reduced warfarin binding of albumin variants

G Wilding, ES Blumberg, and ES Vesell

Binding studies of albumins A/A and A/Me from human plasma and isolated albumin revealed small, but statistically significant, reductions in warfarin binding of albumin A/Me compared to albumin A/A. Such differences in binding in vitro could result in altered pharmacological responses to warfarin administered to individuals possessing albumin A/Me. To determine if clinically significant differences in warfarin distribution exist, observations should be made in vivo on patients of different albumin phenotype who are receiving warfarin therapeutically.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Crystal Structure Analysis of Warfarin Binding to Human Serum Albumin. ANATOMY OF DRUG SITE I.
I. Petitpas, A. A. Bhattacharya, S. Twine, M. East, and S. Curry (2001)
J. Biol. Chem. 276, 22804-22809
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