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Science 11 March 1977:
Vol. 195. no. 4282, pp. 1000 - 1002
DOI: 10.1126/science.841320
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Articles

Science, Vol 195, Issue 4282, 1000-1002
Copyright © 1977 by American Association for the Advancement of Science

articles

Conditioned narcotic withdrawal in humans

CP O'Brien, T Testa, TJ O'Brien, JP Brady, and B Wells

Subjective and physiological manifestations of the narcotic withdrawal syndrome were produced as a conditioned response. Withdrawal reactions precipitated by the narcotic antagonist naloxone in methadone-dependent volunteers were the unconditioned response. These data support clinical anecdotes of withdrawal symptoms occurring in former addicts when they return to their drug-related environment.


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