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Science 4 March 1977: Vol. 195. no. 4281, pp. 880 - 882 DOI: 10.1126/science.402692
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Articles
Science, Vol 195, Issue 4281, 880-882
Copyright © 1977 by American Association for the Advancement of Science
Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia
SS Brem,
PM Gullino,
and
D Medina
Mouse mammary papillomas elicit new formation of vessels when transplanted onto the rabbit iris. This angiogenic capacity is a property of carcinomas but not of the resting mammary gland. In mouse papillary hyperplasias, however, this property appears much earlier than any morphological or clinical sign of carcinoma. A test for angiogenic capacity may reveal a step in the progression toward clinical malignancy and thus could be used to screen for neoplastic potential of hyperplastic epithelium in biopsy tissues.
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