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Science 18 February 1977:
Vol. 195. no. 4279, pp. 683 - 685
DOI: 10.1126/science.190677
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Articles

Science, Vol 195, Issue 4279, 683-685
Copyright © 1977 by American Association for the Advancement of Science

articles

Selective display of histamine receptors on lymphocytes

W Roszkowski, M Plaut, and LM Lichtenstein

Histamine, acting on histamine type 2 receptors, increases intracellular cyclic adenosine monophosphate (AMP) and thus modulates the immunologic functions of lymphocytes. Lymphocyte cyclic AMP levels were used to follow the development of histamine receptors. The B lymphocytes have no functional histamine receptors. As T lymphocytes "mature" in immunologic function--from thymocytes to cortisone-resistant thymocytes to splenic T lymphocytes--their response to histamine increases. The response of these subpopulations of lymphocytes to isoproterenol is the inverse of the histamine response. It is suggested that the changing display of histamine receptors plays an important part in the control of immunologic responses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Activation of the Canonical {beta}-Catenin Pathway by Histamine.
S. H. Diks, J. C. Hardwick, R. M. Diab, M. M. van Santen, H. H. Versteeg, S. J. H. van Deventer, D. J. Richel, and M. P. Peppelenbosch (2003)
J. Biol. Chem. 278, 52491-52496
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