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Science 14 January 1977:
Vol. 195. no. 4274, pp. 189 - 191
DOI: 10.1126/science.831268
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Articles

Science, Vol 195, Issue 4274, 189-191
Copyright © 1977 by American Association for the Advancement of Science

articles

Morphine lowering of self-stimulation thresholds: lack of tolerance with long-term administration

R Esposito and C Kornetsky

Rats were given increasing amounts of morphine over a period of weeks in order to achieve tolerance. Doses of the drug which initially reduced the threshold for self-stimulation behavior continued to do so after long-term administration. These results demonstrate a persistent central effect of morphine which may be related to the opiate "high."


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