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Science 14 January 1977:
Vol. 195. no. 4274, pp. 183 - 185
DOI: 10.1126/science.188135
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Articles

Science, Vol 195, Issue 4274, 183-185
Copyright © 1977 by American Association for the Advancement of Science

articles

Localization of cyclic GMP and cyclic AMP in cardiac and skeletal muscle: immunocytochemical demonstration

SH Ong and AL Steiner

When rat cardiac and skeletal muscle are explored by immunocytochemical procedures designed to show sites of localization of adenosine 3',5'-monophosphate (cyclic AMP) and guanosine 3',5'-monophosphate (cyclic GMP), distinct staining patterns for the two nucleotides are seen. Antibody to cyclic AMP is found in the area of the sarcoplasmic reticulum, while antibody to cyclic GMP is found with a periodic distribution corresponding to that of the A band. This suggests a role for cyclic GMP in the regulation of myosin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production.
S. K. Powers and M. J. Jackson (2008)
Physiol Rev 88, 1243-1276
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