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Science 14 January 1977:
Vol. 195. no. 4274, pp. 181 - 183
DOI: 10.1126/science.188134
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Articles

Science, Vol 195, Issue 4274, 181-183
Copyright © 1977 by American Association for the Advancement of Science

articles

Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor

JM Dayer, R Graham, G Russell, and SM Krane

Human peripheral blood lymphocytes incubated in culture for 1 to 3 days at 37 degree C, but not at 4 degree C, release a soluble factor which can stimulate, up to 400-fold, collagenase production by isolated, adherent, rheumatoid synovial cells. Production of lymphocyte factor is enhanced by phytohemagglutinin or concanavalin A. By gel filtration the factor has an apparent molecular weight of about 12,000.


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