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Science 7 January 1977:
Vol. 195. no. 4273, pp. 80 - 81
DOI: 10.1126/science.831259
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Articles

Science, Vol 195, Issue 4273, 80-81
Copyright © 1977 by American Association for the Advancement of Science

articles

Participation of a nonenzymatic transformation in the biosynthesis of estrogens from androgens

J Goto and J Fishman

The biosynthesis of estrogens from androgens proceeds via three enzymatic hydroxylations, of which the first two take place on the C-19 methyl group and convert it to aldehyde. The final and rate-determining hydroxylation occurs at the 2 beta position, and the product rapidly and nonenzymatically collapses to an estrogen.


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Transient Neonatal Estrogen Exposure to Estrogen-Deficient Mice (Aromatase Knockout) Reduces Prostate Weight and Induces Inflammation in Late Life.
J. J. Bianco, S. J. McPherson, H. Wang, G. S. Prins, and G. P. Risbridger (2006)
Am. J. Pathol. 168, 1869-1878
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Ad4BP/SF-1 Regulates Cyclic AMP-induced Transcription from the Proximal Promoter (PII) of the Human Aromatase P450 (CYP19) Gene in the Ovary.
M. D. Michael, M. W. Kilgore, K.-i. Morohashi, and E. R. Simpson (1995)
J. Biol. Chem. 270, 13561-13566
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