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Science 7 January 1977:
Vol. 195. no. 4273, pp. 72 - 74
DOI: 10.1126/science.831256
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Articles

Science, Vol 195, Issue 4273, 72-74
Copyright © 1977 by American Association for the Advancement of Science

articles

Octopine as an end product of anaerobic glycolysis in the chambered nautilus

PW Hockachka, PH Hartline, and JH Fields

The terminal step in the anaerobic glycolysis of muscle in the chambered nautilus, Nautilus pompilius, is not pyruvate reduction to lactate as in vertebrate muscle. Instead of lactate dehydrogenase, these organisms utilize octopine dehydrogenase (E.C. 1.5.1.11), catalyzing the reductive condensation of pyruvate and arginine, which is dependent on the reduced form of nicotinamide adenine dinucleotide, to form octopine and the oxidized form of the coenzyme. The kinetic properties of octopine dehydrogenase favor the production of octopine, which accumulates under a variety of conditions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Invertebrate and vertebrate pathways of anaerobic metabolism: evolutionary considerations.
D. R. Livingstone (1983)
Journal of the Geological Society 140, 27-37
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Living with water stress: evolution of osmolyte systems.
P. Yancey, M. Clark, S. Hand, R. Bowlus, and G. Somero (1982)
Science 217, 1214-1222
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