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Science 7 January 1977:
Vol. 195. no. 4273, pp. 68 - 70
DOI: 10.1126/science.137524
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Articles

Science, Vol 195, Issue 4273, 68-70
Copyright © 1977 by American Association for the Advancement of Science

articles

Complete reversal of experimental diabetes mellitus in rats by a single fetal pancreas

YS Mullen, WR Clark, IG Molnar, and J Brown

Complete reversal of streptozotocin-induced diabetes mellitus in adult rats will follow transplantation of a single fetal pancreas if the organ is first grown in a normal syngeneic carrier before transfer to the diabetic recipient. Careful control of the blood sugar of diabetic recipients may enhance the function of a single donor organ and thus improve histocompatibility matching.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Subcutaneous transplantation of embryonic pancreas for correction of type 1 diabetes.
S. C. Gunawardana, R. K. P. Benninger, and D. W. Piston (2009)
Am J Physiol Endocrinol Metab 296, E323-E332
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Microencapsulated islets as bioartificial endocrine pancreas.
F Lim and A. Sun (1980)
Science 210, 908-910
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Pancreas Transplantation for Diabetes Mellitus.
J. BROWN, W. R. CLARK, R. K. MAKOFF, H. WEISMAN, J. A. KEMP, and Y. MULLEN (1978)
Ann Intern Med 89, 951-965
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