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Science 24 December 1976:
Vol. 194. no. 4272, pp. 1439 - 1441
DOI: 10.1126/science.827022

Articles

Science, Vol 194, Issue 4272, 1439-1441
Copyright © 1976 by American Association for the Advancement of Science


articles

Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland

T Sakakura, Y Nishizuka, and CJ Dawe

Isografts of heterotypic recombinants of embryonic mammary epithelium with salivary mesenchyme undergo development morphogenetically resembling that of salivary gland. However, cytodifferentiation of the epithelium is like that of mammary gland. In lactating hosts these isografts respond to endogenous hormonal stimulation and synthesize a milk protein, alpha-lactalbumin.


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