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Science 24 December 1976:
Vol. 194. no. 4272, pp. 1437 - 1439
DOI: 10.1126/science.188131
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Articles

Science, Vol 194, Issue 4272, 1437-1439
Copyright © 1976 by American Association for the Advancement of Science

articles

Synaptic transmission: long-lasting potentiation by a postsynaptic mechanism

JA Schulman and FF Weight

Slow decreases of ionic conductance across neuronal cell membranes, which generate slow synaptic potentials, can increase the effectiveness of synaptic transmission. Slow conductance decreases sufficient magnitude increase the amplitude of monosynaptic fast excitatory postsynaptic potentials in B cells of the bullfrog sympathetic ganglion. By this postsynaptic mechanism, activation of one synaptic pathway can cause an increase in transmission, lasting several minutes, across another synapse. This may provide an important mechanism for synaptic integration and control of neuronal interaction.


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Excitatory Muscarinic Modulation Strengthens Virtual Nicotinic Synapses on Sympathetic Neurons and Thereby Enhances Synaptic Gain.
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Synaptic potentials in sympathetic ganglia: are they mediated by cyclic nucleotides?.
N. Busis, F. Weight, and P. Smith (1978)
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