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Science 10 December 1976:
Vol. 194. no. 4270, pp. 1176 - 1178
DOI: 10.1126/science.11560
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Articles

Science, Vol 194, Issue 4270, 1176-1178
Copyright © 1976 by American Association for the Advancement of Science

articles

Presynaptic facilitation as a mechanism for behavioral sensitization in Aplysia

V Castellucci and ER Kandel

Sensitization is an elementary form of nonassociative learning, related to behavioral arousal, in which a strong stimulus facilitates a reflex response. Studies of the neural circuit of the gill-withdrawal reflex in the isolated abdominal ganglion on Aplysia indicate that short-term sensitization is due to presynaptic facilitation. The facilitation results in a sudden increase in the amount of neurotransmitter released by the sensory neurons at their synapses with motor neurons.


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G. D. Nicol, M. R. Vasko, and A. R. Evans (1997)
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Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screening.
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Long-term synaptic changes produced by a cellular analog of classical conditioning in Aplysia.
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Long-term Facilitation in Aplysia: Persistent Phosphorylation and Structural Changes.
S. Schacher, D. Glanzman, A. Barzilai, P. Dash, S.G.N. Grant, F. Keller, M. Mayford, and E.R. Kandel (1990)
Cold Spring Harb Symp Quant Biol 55, 187-202
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cAMP evokes long-term facilitation in Aplysia sensory neurons that requires new protein synthesis.
S Schacher, V. Castellucci, and E. Kandel (1988)
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Long-term facilitation in Aplysia involves increase in transmitter release.
N Dale, S Schacher, and E. Kandel (1988)
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Differential classical conditioning of a defensive withdrawal reflex in Aplysia californica.
T. Carew, R. Hawkins, and E. Kandel (1983)
Science 219, 397-400
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A cellular mechanism of classical conditioning in Aplysia: activity-dependent amplification of presynaptic facilitation.
R. Hawkins, T. Abrams, T. Carew, and E. Kandel (1983)
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What Molecular Steps Determine the Time Course of the Memory for Short-term Sensitization in Aplysia?.
J.H. Schwartz, L. Bernier, V.F. Castellucci, M. Palazzolo, T. Saitoh, A. Stapleton, and E.R. Kandel (1983)
Cold Spring Harb Symp Quant Biol 48, 811-819
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Classical Conditioning and Sensitization Share Aspects of the Same Molecular Cascade in Aplysia.
E.R. Kandel, T. Abrams, L. Bernier, T.J. Carew, R.D. Hawkins, and J.H. Schwartz (1983)
Cold Spring Harb Symp Quant Biol 48, 821-830
   Abstract »    PDF »
Molecular biology of learning: modulation of transmitter release.
E. Kandel and J. Schwartz (1982)
Science 218, 433-443
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Associative learning in Aplysia: cellular correlates supporting a conditioned fear hypothesis.
T. Carew, E. Walters, and E. Kandel (1981)
Science 211, 501-504
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Learning: a model system for physiological studies.
G. Mpitsos, S. Collins, and A. McClellan (1978)
Science 199, 497-506
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Synaptic facilitation and behavioral sensitization in Aplysia: possible role of serotonin and cyclic AMP.
M Brunelli, V Castellucci, and E. Kandel (1976)
Science 194, 1178-1181
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