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Science 3 December 1976:
Vol. 194. no. 4269, pp. 1067 - 1069
DOI: 10.1126/science.982061
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Articles

Science, Vol 194, Issue 4269, 1067-1069
Copyright © 1976 by American Association for the Advancement of Science

articles

Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human bronchi

CC Harris, H Autrup, R Connor, LA Barrett, EM McDowell, and BF Trump

The binding of benzo[a]pyrene to DNA in cultured human bronchus was measured in specimens from 37 patients. The binding values ranged from 2 to 151 picomoles of benzo[a]pyrene per milligram of DNA with an overall mean +/- standard error of 34.2 +/- 5.2. This 75-fold interindividual variation in the binding of benzo[a]pyrene to DNA is similar in magnitude to that found in pharmacogenetic studies of drug metabolism. Aryl hydrocarbon hydroxylase is also inducible by benz[a]anthracene in the bronchial mucosa.


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