Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 October 1976:
Vol. 194. no. 4262, pp. 329 - 330
DOI: 10.1126/science.823643
Prev | Table of Contents | Next

Articles

Science, Vol 194, Issue 4262, 329-330
Copyright © 1976 by American Association for the Advancement of Science

articles

Endocrine-dependent rat mammary tumor regression: use of a gonadotropin releasing hormone analog

ES Johnson, JH Seely, WF White, and ER DeSombre

Long-term administration of [D-Leu6, des-Gly-NH210, Pro-ethylamide9]-GnRH, an analog of gonadotropin releasing hormone, caused regression of neoplastic tissue in a rat bearing a spontaneous mammary adenocarcinoma and in rats in which tumors had been induced by treatment with dimethylbenzanthracene (DMBA). During two separate treatment periods with the analog, the tumor in the single animal regressed although it had previously grown spontaneously. After a third period of growth, ovariectomy also induced regression, suggesting endocrine dependency of the tumor. These observations were confirmed in the DMBA-induced tumor system, where tumor regression in the analog-treated rats was comparable to that observed in the ovariectomized rats, and in both cases the tumor regression was significant when compared to untreated controls.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Extrapituitary action of gonadotropin-releasing hormone: direct inhibition ovarian steroidogenesis.
A. Hsueh and G. Erickson (1979)
Science 204, 854-855
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)