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Science 8 October 1976:
Vol. 194. no. 4261, pp. 204 - 206
DOI: 10.1126/science.986688
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Articles

Science, Vol 194, Issue 4261, 204-206
Copyright © 1976 by American Association for the Advancement of Science

articles

Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate catabolism

AB Clarkson Jr and FH Brohn

When the infected mammalian host of Trypanosoma brucei brucei is injected with a solution of the iron chelator salicyl hydroxamic acid and glycerol, the aerobic and anaerobic glucose catabolism of the parasite is blocked and the parasite is rapidly destroyed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Site-directed Mutagenesis Reveals the Essentiality of the Conserved Residues in the Putative Diiron Active Site of the Trypanosome Alternative Oxidase.
W. U. Ajayi, M. Chaudhuri, and G. C. Hill (2002)
J. Biol. Chem. 277, 8187-8193
   Abstract »    Full Text »    PDF »
Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.
A. M. Aronov, S. Suresh, F. S. Buckner, W. C. Van Voorhis, C. L. M. J. Verlinde, F. R. Opperdoes, W. G. J. Hol, and M. H. Gelb (1999)
PNAS 96, 4273-4278
   Abstract »    Full Text »    PDF »
Prospects for Antiparasitic Drugs. THE CASE OF TRYPANOSOMA BRUCEI, THE CAUSATIVE AGENT OF AFRICAN SLEEPING SICKNESS.
R. Eisenthal and A. Cornish-Bowden (1998)
J. Biol. Chem. 273, 5500-5505
   Abstract »    Full Text »    PDF »
Primary murine bone marrow cultures support continuous growth of infectious human trypanosomes.
A. Balber (1983)
Science 220, 421-423
   Abstract »    PDF »
Role of calcium in trypanocidal drug action.
A. Clarkson Jr and B. Amole (1982)
Science 216, 1321-1323
   Abstract »    PDF »
Comparative biochemistry and drug design for infectious disease.
S. Cohen (1979)
Science 205, 964-971
   Abstract »    PDF »


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