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Science 8 October 1976:
Vol. 194. no. 4261, pp. 199 - 200
DOI: 10.1126/science.959848
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Articles

Science, Vol 194, Issue 4261, 199-200
Copyright © 1976 by American Association for the Advancement of Science

articles

Hyaluronidase-induced reductions in myocardial infarct size

D Maclean, MC Fishbein, PR Maroko, and E Braunwald

The size of myocardial infarctions following coronary artery occlusion in the rat was determined directly by measurement of creatine phosphokinase activity in homogenized whole left ventricles and by planimetric measurement of the area of the infarctions in histologic sections of serial slices of the left ventricles. Hyaluronidase was shown to produce significant reductions in expected infarct size both 48 hours and 3 weeks after occlusion without impairing fibrosis during the healing phase. Thus, the amount of myocardial necrosis that follows a coronary artery occlusion has been shown directly to be amenable to reduction with a pharmacological intervention.


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