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Science 24 September 1976:
Vol. 193. no. 4259, pp. 1249 - 1252
DOI: 10.1126/science.60782
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Articles

Science, Vol 193, Issue 4259, 1249-1252
Copyright © 1976 by American Association for the Advancement of Science

articles

Placental localization of human pregnancy--associated plasma proteins

TM Lin and SP Halbert

Frozen sections of human placenta were examined for the presence of four human pregnancy proteins, pregnancy-associated plasma proteins A and C (PAPP-A and PAPP-C), human chorionic somatomammotropin (hCS), and pregnancy zone protein (PZP), by the indirect immunofluorescence technique. Monospecific rabbit antiserums to PAPP-A, PAPP-C and hCS all stained the trophoblast cytoplasm equivalently in a continuous layer, usggesting that the same trophoblast cells synthesize all three pregnancy proteins. In contrast, PZP was localized in blood vessel walls, parenchymal structures within the villous, as well as in the trophoblast cytoplasm. Its distribution in the latter was relatively inhomogeneous, tending to be more intense on the basement membrane side.


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