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Science 17 September 1976:
Vol. 193. no. 4258, pp. 1135 - 1137
DOI: 10.1126/science.959827
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Articles

Science, Vol 193, Issue 4258, 1135-1137
Copyright © 1976 by American Association for the Advancement of Science

articles

Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2

EF Ellis, O Oelz, LJ Roberts 2nd, NA Payne, BJ Sweetman, AS Nies, and JA Oates

When human platelets are aggregated by thrombin, material is released that rapidly contracts strips of spirally cut porcine coronary artery. Prevention of the contraction by indomethacin suggested mediation by a prostaglandin. The contraction produced by aggregating platelets was unlike those produced by prostaglandins E2, F2alpha, G2, or H2, but resembled that evoked by thromboxane A2, which is formed by platelets during aggregation.


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