Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 September 1976:
Vol. 193. no. 4257, pp. 1015 - 1017
DOI: 10.1126/science.948759
Prev | Table of Contents | Next

Articles

Science, Vol 193, Issue 4257, 1015-1017
Copyright © 1976 by American Association for the Advancement of Science

articles

Cortisol stimulation of parathyroid hormone secretion by rat parathyroid glands in organ culture

WY Au

Addition of cortisol (10(-6) to 10(-8) M) and related glucocorticoid congeners to cultures of rat parathyroid glands stimulated dose-related increases in parathyroid hormone secretion; the addition of deoxycorticosterone or cortexolone was without effect. Cortexolone, however, inhibited the stimulatory activity of cortisol when both were added to the culture medium. This direct stimulatory effect of cortisol on parathyroid gland secretion may account in part for the increased concentration of parathyroid hormone in the serum of cortisol-treated animals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Stimulation of Osteoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in Human Osteoblastic Lineage Cells: Potential Paracrine Mechanisms of Glucocorticoid-Induced Osteoporosis.
L. C. Hofbauer, F. Gori, B. L. Riggs, D. L. Lacey, C. R. Dunstan, T. C. Spelsberg, and S. Khosla (1999)
Endocrinology 140, 4382-4389
   Abstract »    Full Text »
Glucocorticoid Osteoporosis: Reid IR Glucocorticoid osteoporosis J Intensive Care Med 1999, 14231-242.
I. R. Reid (1999)
J Intensive Care Med 14, 231-242
   PDF »
Glucocorticoid Effects on Bone.
I. R. Reid (1998)
J. Clin. Endocrinol. Metab. 83, 1860-1862
   Full Text »
Molecular Cloning and Hormonal Regulation of PiT-1, a Sodium-Dependent Phosphate Cotransporter from Rat Parathyroid Glands.
S. Tatsumi, H. Segawa, K. Morita, H. Haga, T. Kouda, H. Yamamoto, Y. Inoue, T. Nii, K. Katai, Y. Taketani, et al. (1998)
Endocrinology 139, 1692-1699
   Abstract »    Full Text »    PDF »
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Management.
B. P. Lukert and L. G. Raisz (1990)
Ann Intern Med 112, 352-364
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)