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Science 3 September 1976:
Vol. 193. no. 4256, pp. 903 - 905
DOI: 10.1126/science.948751
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Articles

Science, Vol 193, Issue 4256, 903-905
Copyright © 1976 by American Association for the Advancement of Science

articles

Cholesterogenesis: derepression in extrahepatic tissues with 4-aminopyrazolo (3,4-d) pyrimidine

JM Andersen and JM Dietschy

Administration of 4-aminopyrazolo [3,4-d] pyrimidine decreased serum cholesterol levels in the rat to less than 5 milligrams per deciliter. Coincident with this change, there was a 2.1 - to 16.0-fold increase in the rate of sterol synthesis in seven extrahepatic tissues. This suggests that cholesterol carried in serum lipoproteins plays a major role in regulating sterol synthesis in many extrahepatic tissues.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.
M. Brigotti, D. Carnicelli, P. Accorsi, S. Rizzi, L. Montanaro, and S. Sperti (2000)
Nucleic Acids Res. 28, 2383-2388
   Abstract »    Full Text »    PDF »
Developmental and Hormonal Regulation of Murine Scavenger Receptor, Class B, Type 1.
G. Cao, L. Zhao, H. Stangl, T. Hasegawa, J. A. Richardson, K. L. Parker, and H. H. Hobbs (1999)
Mol. Endocrinol. 13, 1460-1473
   Abstract »    Full Text »


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