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Science 20 August 1976:
Vol. 193. no. 4254, pp. 678 - 680
DOI: 10.1126/science.948742
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Articles

Science, Vol 193, Issue 4254, 678-680
Copyright © 1976 by American Association for the Advancement of Science

articles

Multiplication of a human parasite (Leishmania donovani) in phagolysosomes of hamster macrophages in vitro

KP Chang and DM Dwyer

Leishmania donovani, the etiological agent of human visceral leishmaniasis, was grown in hamster peritoneal macrophages in vitro. By electron microscopy, using a lysosomal marker, these parasitic protozoa were seen to multiply within host cell phagolysosomes. The survival mechanism of this intracellular parasite is based apparently upon resistance to macrophage lysosomal enzymic digestion.


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Stage-Specific Activity of Pentavalent Antimony against Leishmania donovani Axenic Amastigotes.
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Inhibition of Phagolysosomal Biogenesis by the Leishmania Lipophosphoglycan.
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Protozoan parasite of humans: surface membrane with externally disposed acid phosphatase.
M Gottlieb and D. Dwyer (1981)
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Novel Intracellular SbV Reducing Activity Correlates with Antimony Susceptibility in Leishmania donovani.
P. Shaked-Mishan, N. Ulrich, M. Ephros, and D. Zilberstein (2001)
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