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Science 13 August 1976:
Vol. 193. no. 4253, pp. 592 - 595
DOI: 10.1126/science.959820
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Articles

Science, Vol 193, Issue 4253, 592-595
Copyright © 1976 by American Association for the Advancement of Science

articles

Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo

IB Weinstein, AM Jeffrey, KW Jennette, SH Blobstein, RG Harvey, C Harris, H Autrup, H Kasai, and K Nakanishi

Evidence has been obtained that a specific isomer of a diol epoxide derivative of benzo(a)pyrene, (+/-)-7 beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, is an intermediate in the binding of benzo(a)pyrene to RNA in cultured bovine bronchial mucosa. An adduct is formed between position 10 of this derivative and the 2-amino group of guanine.


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