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Science 6 August 1976:
Vol. 193. no. 4252, pp. 498 - 500
DOI: 10.1126/science.941022
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Articles

Science, Vol 193, Issue 4252, 498-500
Copyright © 1976 by American Association for the Advancement of Science

articles

Markers for detection of supplementation in narcotic programs--deuterium-labeled methadone

JC Hsia, JC Tam, HG Giles, CC Leung, H Marcus, JA Marshman, and AE Leblanc

Specific deuterium labeling of methadone and use of gas chromatography-mass spectroscopy technique permits rapid and quanitative determination of the ratio of the labeled to unlabeled drug in body fluids. A trideuertiomethadone (methadone-d3) was shown to have exactly the same analgesic activity and toxicity in mice as methadone. The rates of absorption, distribution, and excretion of methadone-d3 and methadone were identical in rats. These observations suggest that methadone-d3 may be used as an in vivo marker for monitoring methadone intake of patients, and thus may improve the effectiveness of methadone treatment programs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Simultaneous quantitative determination of deuterium- and carbon-13-labeled essential fatty acids in rat plasma.
Y. H. Lin, R. J. Pawlosky, and N. Salem Jr. (2005)
J. Lipid Res. 46, 1974-1982
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