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Science 2 July 1976:
Vol. 193. no. 4247, pp. 62 - 64
DOI: 10.1126/science.935855
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Articles

Science, Vol 193, Issue 4247, 62-64
Copyright © 1976 by American Association for the Advancement of Science

articles

Cross-linking of DNA in situ as a probe for chromatin structure

CV Hanson, CK Shen, and JE Hearst

The photochemical cross-linking of DNA in situ in chromatin is blocked over short intervals. Electron microscopy of DNA cross-linked in chromatin reveals the lengths of protected regions and provides a map of their sites along the DNA. Protected regions occur most frequently in tandem and have a basic length of 160 to 200 base pairs.


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Sharp Kink of DNA at Psoralen-cross-link Site Deduced from Crystal Structure of Psoralen-Thymine Monoadduct.
S.-H. Kim, S. Peckler, B. Graves, D. Kanne, H. Rapoport, and J.E. Hearst (1983)
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Chromatin Structures of Main-band and Satellite DNAs in Drosophila melanogaster Nuclei as Probed by Photochemical Cross-linking of DNA with Trioxsalen.
C.-K. J. Shen and J. E. Hearst (1978)
Cold Spring Harb Symp Quant Biol 42, 179-189
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Chromatin Structure in Living Cells.
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Cold Spring Harb Symp Quant Biol 42, 191-198
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Summary: The Molecular Biology of the Eukaryotic Genome Is Coming of Age.
P. Chambon (1978)
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Psoralen-DNA photoreaction: controlled production of mono- and diadducts with nanosecond ultraviolet laser pulses.
B. Johnston, M. Johnson, C. Moore, and J. Hearst (1977)
Science 197, 906-908
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