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Science 2 July 1976:
Vol. 193. no. 4247, pp. 58 - 59
DOI: 10.1126/science.180596
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Articles

Science, Vol 193, Issue 4247, 58-59
Copyright © 1976 by American Association for the Advancement of Science

articles

Ethanol-induced depletion of cerebellar guanosine 3',5' -cyclic monophosphate

JD Redos, GN Catravas, and WA Hunt

Single doses of ethanol a severe depletion (95 percent) of cerebellar guanosine 3',5' -cyclic monophosphate (cyclic GMP) within 1 hour after administration. The degree of this depletion is dose-dependent and is a function of the amount of ethanol in the blood. Interactions between ethanol and cyclic GMP may account for some of the intoxicating properties of ethanol.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)