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Science 25 June 1976:
Vol. 192. no. 4246, pp. 1337 - 1339
DOI: 10.1126/science.131972
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Articles

Science, Vol 192, Issue 4246, 1337-1339
Copyright © 1976 by American Association for the Advancement of Science

articles

Tropomyosin binding to F-actin induced by myosin heads

BL Eaton

Tropomyosin is a regulatory protein associated with F-actin in many actomyosin contractile systems. If in vitro conditions are such that tropomyosin binds only slightly to F-actin, then the addition of myosin heads can induce stoichiometric binding between them. This suggests that formation of rigor bonds between actin and myosin heads may cause some change in the actin, stabilizing the appropriate binding site for tropomyosin.


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