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Science 11 June 1976:
Vol. 192. no. 4244, pp. 1132 - 1134
DOI: 10.1126/science.179142
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Articles

Science, Vol 192, Issue 4244, 1132-1134
Copyright © 1976 by American Association for the Advancement of Science

articles

Ion-exchange in melanin: an electron spin resonance study with lanthanide probes

T Sarna, JS Hyde, and HM Swartz

Changes are induced in the electron spin resonance signal amplitude and microwave power saturation of the naturally occurring free radical in melanin by bound paramagnetic ions. The changes serve as experimental observables in competition experiments between diamagnetic and paramagnetic metal ions for melanin binding sites and between melanin and ethylenediaminetetraacetic acid for paramagnetic metal ions. Evidence is presented for the existence of several specific types of metal binding sites. The interaction of copper with free radicals leading to loss of electron spin resonance signal amplitude is magnetic in nature and not, as has been supposed, chemical.


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Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.
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Magnetic Resonance Imaging Evidence of Decreased Putamenal Iron Content in Idiopathic Parkinson's Disease.
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