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Science 4 June 1976:
Vol. 192. no. 4243, pp. 1018 - 1020
DOI: 10.1126/science.1273584
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Articles

Science, Vol 192, Issue 4243, 1018-1020
Copyright © 1976 by American Association for the Advancement of Science

articles

Monoamine oxidase activity decreased in cells lacking hypoxanthine phosphoribosyltransferase activity

XO Breakefield, CM Castiglione, and SB Edelstein

The Lesch-Nyhan syndrome in humans is characterized by lack of hypoxanthine phosphoribosyltransferase activity and neurologic abnormalities that suggest changes in catecholamine metabolism. Monoamine oxidase, which degrades biogenic amines, has decreased activity in noradrenergic murine neuroblastoma cell lines lacking hypoxanthine phosphoribosyltransferase activity and in skin fibroblasts from patients with the Lesch-Nyhan syndrome.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Monoamine Oxidase and Criminality: Identifying an Apparent Biological Marker for Antisocial Behavior.
L. ELLIS (1991)
Journal of Research in Crime and Delinquency 28, 227-251
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Hypoxanthine-guanine phosphoribosyltransferase mutant glioma cells: diminished monamine oxidase activity.
S. Skaper and J. Seegmiller (1976)
Science 194, 1171-1173
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