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Science 4 June 1976:
Vol. 192. no. 4243, pp. 1011 - 1012
DOI: 10.1126/science.1273582
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Articles

Science, Vol 192, Issue 4243, 1011-1012
Copyright © 1976 by American Association for the Advancement of Science

articles

Sodium arachidonate can induce platelet shape change and aggregation which are independent of the release reaction

RL Kinlough-Rathbone, HJ Reimers, JF Mustard, and MA Packham

Sodium arachidonate causes shape change and aggregation of rabbit or human platelets that have been washed and then degranulated by treatment with thrombin. Since these platelets do not contain releasable adenosine diphosphate (ADP) and the aggregation is not inhibited by the creatine phosphate-creatine phosphokinase system, sodium arachidonate must be able to cause aggregation that is independent of the release of ADP. Since aggregation of these platelets induced by sodium arachidonate is inhibited by acetylsalicylic acid or indomethacin, it seems likely that products (such as prostaglandin G2) formed from sodium arachidonate are responsible for aggregation. Thus, sodium arachidonate-induced shape change and aggregation of platelets may be caused (i) by the release of ADP by products of sodium arachidonate metabolism and (ii) directly by the products of sodium arachidonate metabolism, independently of released ADP.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The P2Y12 Antagonists, 2-Methylthioadenosine 5'-Monophosphate Triethylammonium Salt and Cangrelor (ARC69931MX), Can Inhibit Human Platelet Aggregation through a Gi-independent Increase in cAMP Levels.
S. Srinivasan, F. Mir, J.-S. Huang, F. T. Khasawneh, S. C.-T. Lam, and G. C. Le Breton (2009)
J. Biol. Chem. 284, 16108-16117
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