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Science 4 June 1976:
Vol. 192. no. 4243, pp. 1007 - 1008
DOI: 10.1126/science.944951
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Articles

Science, Vol 192, Issue 4243, 1007-1008
Copyright © 1976 by American Association for the Advancement of Science

articles

Alpha-methylphenylalanine, a new inducer of chronic hyperphenylalaninemia in sucling rats

O Greengard, MS Yoss, and JA Del Valle

alpha-Methylphenylalanine reduces the phenylalanine hydroxylase activity of rat liver by 75 percent. Daily injections of this substance (plus phenylalanine) into rats from the 3rd to 15th day of age had no obvious toxic effects, and maintained a plasma concentration of phenylalanine comparable to that of phenylketonuric subjects.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Experimental phenylketonuria: replacement of carboxyl terminal tyrosine by phenylalanine in infant rat brain tubulin.
J. Rodriguez and G. Borisy (1979)
Science 206, 463-465
   Abstract »    PDF »
Hyperphenylalanemia: effect on brain polyribosomes can be partially reversed by other amino acids.
J. Hughes and T. Johnson (1977)
Science 195, 402-404
   Abstract »    PDF »


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