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Science 28 May 1976:
Vol. 192. no. 4242, pp. 902 - 904
DOI: 10.1126/science.179139
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Articles

Science, Vol 192, Issue 4242, 902-904
Copyright © 1976 by American Association for the Advancement of Science

articles

Neural properties of cultured human endocrine tumor cells of proposed neural crest origin

AS Tischler, MA Dichter, B Biales, RA DeLellis, and H Wolfe

Cells from human endocrine tumors of proposed neural crest origin--five pheochromocytomas, two medullary carcinomas of the thyroid, and two bronchial carcinoids--were grown in monolayer culture. Cells from all nine tumors, including epithelial forms of medullary carcinoma of the thyroid and bronchial carcinoid cells, and epithelial and neuron-like pheochromocytoma cells demonstrated all-or-nothing, short-duration action potentials.


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