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Science 7 May 1976:
Vol. 192. no. 4239, pp. 569 - 572
DOI: 10.1126/science.130679
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Articles

Science, Vol 192, Issue 4239, 569-572
Copyright © 1976 by American Association for the Advancement of Science

articles

Models of carcinogenesis as an escape from mitotic inhibitors

GI Bell

Diffusible mitotic inhibitors are assumed to govern proliferation of normal cells. Cancer cells may escape regulation by failing to either recognize or secrete inhibitors. In the latter case, probabilities and expected times for reaching a critical clone size are given. Patterns of proliferation will depend on whether the inhibitor concentration is locally or systemically determined.


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