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Science 7 May 1976:
Vol. 192. no. 4239, pp. 563 - 565
DOI: 10.1126/science.1257792
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Articles

Science, Vol 192, Issue 4239, 563-565
Copyright © 1976 by American Association for the Advancement of Science

articles

Complement-dependent immunoglobulin G receptor function in lymphoid cells

JC Scornik

Lymphoid cells are unable to lyse antibody-coated target cells in the presence of normal immunoglobulin G (IgG), presumably because their surface receptors of IgG are blocked. However, when target cells are sensitized with antibodies and complement, IgG receptors are unblocked and cytotoxicity occurs even in the presence of normal IgG. Thus, IgG receptors may function in vivo despite the relatively high concentations of IgG in serum and interstitial fluid.


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